BOSTON (AP) — It seems David Ortiz is becoming more dangerous with each swing.

Ortiz homered for the second straight game in the World Series, sending a drive over the Green Monster on Thursday night. Despite the shot, Boston lost to St. Louis 4-2, leaving the teams tied at 1-all.

"My key? I'll let you know after the World Series is over," he said. "I'm not going to tell you all of my secrets now."

Big Papi hit his fifth homer of this postseason — in 41 at-bats and 17th overall. He is tied for seventh overall with Jim Thome, one behind Mickey Mantle, Reggie Jackson and Albert Pujols. Manny Ramirez leads that list with 29.

Ortiz connected for a two-run shot in the sixth off Michael Wacha, ending the 22-year-old's scoreless streak at 18 2-3 innings, a rookie record in a single postseason.

"With this lineup that Boston has, you can't make mistakes or they'll let you pay. A good hitter like Ortiz, I made a mistake, 3-2 changeup up in the zone, and he made me pay," Wacha said.

After two days as a designated hitter, Ortiz will have to play the field to start Game 3 at St. Louis on Saturday night. The veteran DH has spent some time at first base, and did well there in 2004 when the Red Sox swept St. Louis.

If Ortiz moves to first base, he'll bump Mike Napoli from the lineup. Napoli was a catcher earlier in his career, but manager John Farrell said he won't put him behind the plate.

So, Ortiz has got his glove ready.

"It's likely that Game 3 he'll be at first base at this point, just a quick look at it," Farrell said. "And how we go from there, we'll go to it day to day. But again we're going to lose one of the middle-of-the-order bats, and that's understood going in. But still David's in a pretty good place right now offensively."

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BATTING THIRD: Dustin Pedroia spent most of his career hitting second in the Boston Red Sox lineup. Until this year.

The diminutive second baseman batted third 147 times this season and hasn't had to make much of an adjustment with sluggers David Ortiz and Mike Napoli hitting behind him.

"It hasn't changed my offensive approach," Pedroia said before Game 2 of the World Series against the St. Louis Cardinals. "I still try to do the same things. Sometimes on the bases with David hitting behind me, if they're not shifting him as much and he can hit with that hole, I won't run as much."

And he certainly doesn't hit with the power of a traditional No. 3 hitter.

The 5-foot-8, 165-pound Pedroia hit nine homers this year and had a total of 45 the past three years.

"I'm a run scorer, get on base and try to make something happen," Pedroia said, "hit the ball in the gaps, make the big hits, move runners, do everything. I don't look at it like I'm Miguel Cabrera and hit 40 home runs or things like that. I just try to play the game and do all I can."

The 6-foot-4, 240-pound Miguel Cabrera hit 44 homers this season and last season with the Detroit Tigers.

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CARDINALS CHANGEUP: St. Louis Cardinals manager Mike Matheny made two changes in his starting lineup for Game 2 of the World Series.

And Daniel Descalso started for Pete Kozma at shortstop. Kozma made errors in each of the first two innings, helping the Red Sox to five runs in their 8-1 win over the Cardinals.

Kozma entered in the seventh inning as part of a double switch and responded by making a couple of nice plays.

"Regardless of what may have happened yesterday, he is a plus defender and we have a lot of confidence in him. So we want to get him in the game," manager Mike Matheny said.

Also, Jon Jay started in place of Shane Robinson in center field.

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STICKY SITUATION: Pedro Martinez fired a high, hard one at the Cardinals.

The former Red Sox star said that St. Louis didn't lose Game 1 of the World Series because Boston ace Jon Lester had rosin on his glove.

"It's not about what he had in his glove," Martinez said. "It's about how bad St. Louis came out to play. They did not execute. They did not do anything right, and Lester had everything going on for him. That's all you had to look at. St. Louis was flat. Lester had his good stuff and he beat them. That's it. Clean and simple. That's it."

Martinez spoke before Game 2 at a news conference with two teammates from the 2004 Red Sox championship team, pitcher Derek Lowe and outfielder Trot Nixon.

After Boston's 8-1 win on Wednesday night, Cardinals minor league pitcher Tyler Melling posted a screen shot on Twitter showing a green substance on Lester's glove.

Lester and Red Sox manager John Farrell said Thursday that the substance was only rosin, which is legal. They both said Lester sweats a lot and uses the rosin to get a better grip on the ball.

Cardinals outfielder Shane Robinson went 1 for 3 against Lester and said Thursday he didn't see "anything out of the norm" while watching video.

"We just didn't put together any kind of streak of hits in a row to get any runs off of him," he said.