ORANGE, Calif. (AP) _ Frederick Reines, a Nobel Prize-winning physicist known as the father of neutrino physics for his groundbreaking research on particle physics, died Wednesday from complications of Parkinson's disease. He was 80.

Reines, who was a physics professor at the University of California, first began his research on neutrinos in 1951 while at a laboratory in New Mexico. He produced the ghostlike, virtually massless subatomic particles with a nuclear reactor so that he could detect them using a tank of water as the agent of detection.

His career in neutrino physics culminated in 1995, when he and Martin L. Perl shared a Nobel Prize in physics for pioneering experimental contributions to lepton physics.

For seven years beginning in 1959, Reines headed the physics department at Case Institute of Technology, now Case Western Reserve University.

In 1966, Reines became the founding dean of physical sciences at the then-new University of California, Irvine. He led a team of scientists whose research on neutrinos from supernova 1987A won the Bruno Rossi prize in high-energy physics from the American Astronomical Society.