214, Jay Ajayi, MIA vs. BUF 10/23 (28 att., 1 TD)

204, Jay Ajayi, MIA vs. PIT 10/16 (25 att., 2 TD)

168, Jeremy Hill, CIN vs. CLE 10/23 (9 att., 1 TD)

157, David Johnson, ARI at SNF 10/6 (27 att., 2 TD)

157, Ezekiel Elliott, DAL at GBY 10/16 (28 att., 0 TD)

154, Jacquizz Rodgers, TAM at SNF 10/23 (26 att., 0 TD)

153, Jordan Howard, CHI vs. MIN 10/31 (26 att., 1 TD)

152, Devonta Freeman, ATL at NOR 9/26 (14 att., 0 TD)

150, LeSean McCoy, BUF at LA 10/9 (18 att., 0 TD)

149, Lamar Miller, HOU vs. IND 10/16 (OT) (24 att., 1 TD)

144, Le'Veon Bell, PIT vs. KAN 10/2 (18 att., 0 TD)

143, DeAngelo Williams, PIT at WAS 9/12 (26 att., 2 TD)

140, Ezekiel Elliott, DAL vs. CHI 9/25 (30 att., 0 TD)

140, LeSean McCoy, BUF vs. SNF 10/16 (19 att., 3 TD)

138, Ezekiel Elliott, DAL at SNF 10/2 (23 att., 1 TD)

135, Matt Jones, WAS vs. PHL 10/16 (16 att., 1 TD)

134, Ezekiel Elliott, DAL vs. CIN 10/9 (15 att., 2 TD)

133, Isaiah Crowell, CLE vs. BAL 9/18 (18 att., 1 TD)

131, Spencer Ware, KAN at OAK 10/16 (24 att., 1 TD)

127, LeGarrette Blount, NWE at PIT 10/23 (24 att., 2 TD)

123, LeGarrette Blount, NWE vs. MIA 9/18 (29 att., 1 TD)

123, DeMarco Murray, TEN vs. JAX 10/27 (21 att., 1 TD)

121, DeMarco Murray, TEN at MIA 10/9 (27 att., 0 TD)

120, Isaiah Crowell, CLE at WAS 10/2 (16 att., 1 TD)

118, Jordan Howard, CHI at IND 10/9 (16 att., 0 TD)

117, Matt Jones, WAS vs. CLE 10/2 (22 att., 1 TD)

114, DeMarco Murray, TEN vs. OAK 9/25 (16 att., 1 TD)

113, Terrance West, BAL vs. OAK 10/2 (21 att., 1 TD)

113, David Johnson, ARI vs. SEA 10/23 (OT) (33 att., 0 TD)

111, Jordan Howard, CHI vs. DET 10/2 (23 att., 0 TD)

111, David Johnson, ARI vs. NYJ 10/17 (22 att., 3 TD)

111, Melvin Gordon, SND at DEN 10/30 (23 att., 0 TD)

110, LeSean McCoy, BUF vs. ARI 9/25 (17 att., 2 TD)

107, C.J. Anderson, DEN vs. HOU 10/24 (16 att., 1 TD)

107, DeMarco Murray, TEN vs. IND 10/23 (25 att., 1 TD)

106, Lamar Miller, HOU vs. CHI 9/11 (28 att., 0 TD)

106, Christine Michael, SEA vs. SNF 9/25 (20 att., 2 TD)

106, Frank Gore, IND at HOU 10/16 (OT) (22 att., 0 TD)

105, LeGarrette Blount, NWE vs. HOU 9/22 (24 att., 2 TD)

104, Kevin Hogan, CLE at CIN 10/23 (7 att., 1 TD)

103, Eddie Lacy, GBY vs. DET 9/25 (17 att., 0 TD)

103, Carlos Hyde, SNF at SEA 9/25 (21 att., 2 TD)

102, Melvin Gordon, SND vs. JAX 9/18 (24 att., 1 TD)

102, Tim Hightower, NOR vs. SEA 10/30 (26 att., 0 TD)

101, Jacquizz Rodgers, TAM at CAR 10/10 (30 att., 0 TD)

100, Fozzy Whittaker, CAR vs. SNF 9/18 (16 att., 0 TD)

100, Matt Forte, NYJ at BUF 9/15 (30 att., 3 TD)

100, Matt Forte, NYJ vs. BAL 10/23 (30 att., 1 TD)