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Prana Biotechnology: Pre-Clinical Evidence Demonstrates PBT434 as a Potential Treatment for MSA

October 5, 2018

MELBOURNE, Australia & SAN FRANCISCO--(BUSINESS WIRE)--Oct 4, 2018--Prana Biotechnology Ltd (ASX: PBT) (NASDAQ: PRAN) today announced further pre-clinical evidence for PBT434 will be presented in a poster at the International Congress of Parkinson’s Disease and Movement Disorders® in Hong Kong on Sunday, October 7 th, 2018 at 1:45pm.

The poster is entitled ‘PBT434 prevents the accumulation of glial cell inclusions and insoluble alpha-synuclein in a mouse model of Multiple System Atrophy’. Multiple System Atrophy (MSA) is a fatal neurodegenerative disease and an important form of atypical Parkinsonism. The data demonstrate in the most widely accepted animal model of the disease that PBT434 prevents α-synuclein aggregation, preserves neurons, decreases the number of glial cell inclusions and slows motor dysfunction. Glial cell inclusions are the key pathological finding in MSA and contain abundant aggregated α-synuclein that is associated with neurodegeneration. Alpha-synuclein is of great interest to scientists and clinicians because aggregated forms of the protein are toxic and underlie the pathology of neurological diseases such as MSA and Parkinson’s disease.

“We are excited to share these data with the movement disorder community because Multiple System Atrophy is a terrible disease and has no approved treatments. The data indicate that PBT434 targets the key pathology in MSA and has excellent potential to treat this devastating condition. Our Phase 1 study in healthy volunteers is ongoing and we look forward to bringing PBT434 to patient studies in the future”, said David Stamler, Chief Medical Officer and Senior Vice President of Clinical Development.

PBT434 is the first of a new generation of small molecules designed to inhibit the aggregation of α-synuclein and tau, vital intracellular proteins that are implicated in neurodegenerative diseases such as Parkinson’s disease and atypical Parkinsonism.

For further information please visit the Company’s web site at www.pranabio.com.

View source version on businesswire.com:https://www.businesswire.com/news/home/20181004005905/en/

CONTACT: Investor Relations

WE Buchan

Ben Walsh, +61 422 520 012

bwalsh@we-buchan.com

Media

WE Buchan

Scott Newstead, +61 3 9866 4722

snewstead@we-buchan.com

KEYWORD: AUSTRALIA UNITED STATES ASIA PACIFIC NORTH AMERICA AUSTRALIA/OCEANIA CALIFORNIA HONG KONG

INDUSTRY KEYWORD: HEALTH BIOTECHNOLOGY CLINICAL TRIALS PHARMACEUTICAL

SOURCE: Prana Biotechnology Limited

Copyright Business Wire 2018.

PUB: 10/04/2018 11:47 PM/DISC: 10/04/2018 11:47 PM

http://www.businesswire.com/news/home/20181004005905/en

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