DETROIT (0-1) at SAN FRANCISCO (0-1)

Sunday, 4:05 p.m. ET, Fox

OPENING LINE - 49ers by 3 1/2

RECORD VS. SPREAD - Detroit 0-1, San Francisco 0-1

SERIES RECORD - 49ers lead 37-28-1

LAST MEETING - Lions beat 49ers 32-17, Dec. 27, 2015

LAST WEEK - Lions lost to Jets 48-17; 49ers lost at Vikings 24-16

AP PRO32 RANKING - Lions No. 30, 49ers No. 23

LIONS OFFENSE - OVERALL (17), RUSH (32), PASS (8).

LIONS DEFENSE - OVERALL (19), RUSH (30), PASS (10).

49ERS OFFENSE - OVERALL (20), RUSH (24), PASS (15).

49ERS DEFENSE - OVERALL (18), RUSH (17), PASS (16).

STREAKS, STATS AND NOTES - Lions lost nine straight in series before win in 2015. ... Detroit lost 12 straight at San Francisco since 28-17 win Nov. 2, 1975. ... Lions coming off most lopsided season-opening loss since 45-0 defeat at Washington in 1991. ... Detroit allowed TDs on run, pass, punt return, INT return vs. Jets. ... Lions QB Matthew Stafford threw four INTs in opener. ... Detroit gained league-low 39 yards rushing in opener. ... San Francisco QB Jimmy Garoppolo had first loss in eight NFL starts last week. Garoppolo is first 49ers QB with three INTs in opener since Steve Young in 1993. ... San Francisco has 12 TDs on 28 red-zone drives with Garoppolo as starter past two seasons. ... 49ers went three-and-out on three of 12 drives in opener after doing it on 4 of 49 non-kneeldown drives in Garoppolo's starts last year. ... Rookie WR Dante Pettis became first 49er to score TD on first career catch since Vernon Davis in 2006. ... San Francisco DL DeForest Buckner had 2 1/2 sacks last week after only three in all of 2017. ... 49ers LB Fred Warner led all rookies with 12 tackles last week. Warner also forced fumble. ... San Francisco K Robbie Gould made 26 straight FGs, one shy of Phil Dawson's franchise record. ... Fantasy tip: San Francisco's George Kittle had fourth-most targets of any TE in Week 1 with nine. He caught five for 50 yards and Lions had trouble covering everybody vs. Jets.

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