ORCHARD PARK, N.Y. (AP) — The Buffalo Bills will be short-handed on the offensive line when they face the Houston Texans and the best pass rusher in the league on Sunday.

Right guard John Miller (ankle) is out for the second week in a row and right tackle Seantrel Henderson (illness) is doubtful and not expected to play against J.J. Watt and the Texans.

"Well, that's going to be a challenge, there's no doubt," Bills coach Rex Ryan said. "Our scout team's doing the best J.J. Watt they can do, but obviously it might be a little upgrade on the game. But this is all you can do, so we'll see. Obviously, we recognize the fact that he's a great player."

Guard Kraig Urbik and tackle Jordan Mills will start in their place. It will be Mills' first start with the Bills; Mills started 29 games for the Chicago Bears from 2013-14.

Buffalo also will be without linebacker Nigel Bradham (ankle) and running back Karlos Williams (shoulder). Ryan said the Bills will add running back Mike Gillislee to the active roster from the practice squad before the game on Sunday.

Defensive end Mario Williams (foot) is probable and expected to return after missing one game. Seven weeks after voicing his concerns about Buffalo's defensive scheme, Williams said Friday the Bills are still "doing the same thing" on defense and have not made any major schematic changes.

With just three sacks in 10 games, Williams said he still has what it takes to get double-digit sacks when used in his traditional pass-rushing role.

"Yeah, definitely. I'm not worried about that," Williams said. "I bring it. When I'm on the edge, you see that. That's no difference. Whenever you're doing what you've been doing, you're not teaching new tricks to an old dog. Nah, I'm not worried about that at all."