NANOBIOTIX' MANAGEMENT STATEMENT ON RECENT SHARE PRICE VARIATION

Paris, France and Cambridge, Massachusetts, USA, June 6 2018 - NANOBIOTIX (Euronext: NANO - ISIN: FR0011341205), a late clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, communicates today regarding the recent evolution of its share price.

The Company noticed a significant decrease of its share price over the last few days. The management confirms that no news or particular event, that would not have been disclosed to the public, has happened.

Some inquiries have emerged regarding the inclusion or exclusion criteria in the Soft Tissue Sarcoma Phase II/III trial. The update made on the website www.ClinicalTrials.gov regarding this trial, is a technical update related to a protocol amendment that has been implemented in 2015.

The Company will publish Soft Tissue Sarcoma top line data as soon as it is available and before the end of June as expected.

Nanobiotix pursues its development and strategy according to plans.

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About NANOBIOTIX: www.nanobiotix.com Incorporated in 2003, Nanobiotix is a leading, late clinical-stage nanomedicine company pioneering new approaches to significantly change patient outcomes by bringing nanophysics to the heart of the cell.

The Nanobiotix philosophy is one rooted in designing pioneer physical based approaches to bring highly effective and generalized solutions to address high unmet medical needs and challenges.

The Company's first-in-class, proprietary lead technology, NanoXray, aims to expand radiotherapy benefits for millions of cancer patients. Furthermore, the Company's Immuno-Oncology program has the potential to bring a new dimension to cancer immunotherapies.

Nanobiotix is listed on the regulated market of Euronext in Paris (Euronext: NANO / ISIN: FR0011341205; Bloomberg: NANO: FP). The Company's Headquarters are based in Paris, France, with a U.S. affiliate in Cambridge, MA, and european affiliates in Spain and Germany.

Contact

Nanobiotix ---------------------------------------------------------------------------------------------------- Sarah Gaubert Director, Communication & Public Affairs Noël Kurdi Ricky Bhajun +33 (0)1 40 26 07 55 Director, Investor Relations Investor Relations Europe sarah.gaubert@nanobiotix.com +1 (646) 241-4400 +33 (0)1 79 97 29 99 / noel.kurdi@nanobiotix.com / ricky.bhajun@nanobiotix.com / contact@nanobiotix.com investors@nanobiotix.com investors@nanobiotix.com ---------------------------- Media relations ---------------------------------------------------------------------- France - Springbok United States - Consultants RooneyPartners Marina Rosoff Marion Janic +33 (0)6 71 58 00 34 +1 (212) 223-4017 marina@springbok.fr mjanic@rooneyco.com

Disclaimer This press release contains certain forward-looking statements concerning Nanobiotix and its business. Such forward-looking statements are based on assumptions that Nanobiotix considers to be reasonable. However, there can be no assurance that the estimates contained in such forward-looking statements will be verified, which estimates are subject to numerous risks including the risks set forth in the reference document of Nanobiotix filed with the French Financial Markets Authority (Autorité des Marchés Financiers) under number D.17-0470 on April 28, 2017 as well as in its 2017 annual financial report filed with the French Financial Markets Authority on March 29, 2018 (a copy of which is available on www.nanobiotix.com) and to the development of economic conditions, financial markets and the markets in which Nanobiotix operates. The forward-looking statements contained in this press release are also subject to risks not yet known to Nanobiotix or not currently considered material by Nanobiotix. The occurrence of all or part of such risks could cause actual results, financial conditions, performance or achievements of Nanobiotix to be materially different from such forward-looking statements. This press release and the information that it contains do not constitute an offer to sell or subscribe for, or a solicitation of an offer to purchase or subscribe for, Nanobiotix shares in any country. At the moment NBTXR3 does not bear a CE mark and is not permitted to be placed on the market or put into service until NBTXR3 has obtained a CE mark.