CORNWELLS HEIGHTS, Pa. (AP) _ A confused motorist driving the wrong way on an interstate collided with a car full of college students that was traveling at 80 to 100 mph, killing all six people in the two cars, police said.

Cheryl Meisner, 23, of East Windsor, N.J., was driving south early Sunday but apparently didn't realize she was in the northbound lanes of Interstate 95 police said. She struck a northbound car carrying five students from Trenton State College, in southern New Jersey.

Four other people suffered minor injuries when their car struck the wreckage, state police said.

Police in Middletown, Bristol and Bensalem attempted to intercept Ms. Meisner before the accident.

''Evidently the operator of the southbound car was bewildered,'' said state trooper Karl Grill. ''Speculation is that she traveled roughly 10 miles in the wrong lanes, passing vehicles along the way. She apparently did not realize that she was on an interstate highway, headed in the wrong direction.''

A witness to the accident said he had seen the students at a street race in Philadelphia, Grill said.

''The witness was on a motorcycle, and he said he was passed by the car about half a mile before the accident. He estimated his speed at 65 mph, and he said the car passed him like he was standing still,'' the trooper said.

Debris from the accident littered the highway, forcing police to close a section of I-95 until about 8 a.m. Sunday.

A spokeswoman at Trenton State College identified the five students as Philip Prisco and Terence Morgan of Ringwood, N.J.; Daniel Nulman of Clinton, N.J.; Domenick Nocito of Somerdale, N.J., and Allen DeRogatis of Absecon Highlands, N.J.

Spokeswoman Sylvia Hutchinson said Morgan and Prisco were freshmen and DeRogatis was a sophomore, Nocito a junior and Nulman a senior.

Trenton State President Harold W. Eickhoff, in a statement issued through Ms. Hutchinson, said, ''My wife, Rosa Lee, and I share in the sorrow of the families and friends of these young men.''

Eickhoff ordered flags on campus lowered to half-staff for the next week, and said the college would hold a memorial service for the students, according to Ms. Hutchinson.