VBI Vaccines’ Late-Breaker Cytomegalovirus Abstract Chosen for Oral Presentation at IDWeek 2018
-- Presentation to feature complete safety and immunogenicity dataset from the Phase 1 clinical study of VBI-1501 -- Oral presentation at IDWeek 2018 on Saturday, October 6th, 2018, at 11:10 AM PDT
CAMBRIDGE, Mass., Oct. 02, 2018 (GLOBE NEWSWIRE) -- VBI Vaccines Inc. (NASDAQ: VBIV) (“VBI”), a commercial-stage biopharmaceutical company, today announced that, based on the quality and scientific content, the company’s late-breaker abstract, “An Enveloped Virus-like Particle (eVLP) Cytomegalovirus (CMV) Vaccine is Immunogenic and Safe: Results of a First-in-Humans Study,” has been selected for oral presentation at IDWeek 2018, in San Francisco, CA, on October 6, 2018.
Dr. Soren Gantt, M.D., Ph.D., MPH, Associate Professor with the Division of Infectious Disease in the Department of Pediatrics, University British Columbia Faculty of Medicine, BC Children’s Hospital, and an investigator of the VBI-1501 Phase I study, will deliver the oral presentation. Dr. Gantt’s presentation will discuss the complete safety and immunogenicity dataset from the Phase 1, randomized, placebo-controlled clinical study evaluating the company’s prophylactic CMV vaccine candidate, VBI-1501. This multicenter first-in-humans study was conducted in collaboration with the Canadian Immunization Research Network (CIRN), and showed that VBI-1501 was safe and well tolerated at all doses tested.
Additionally, VBI-1501 was shown to induce gB antibody binding titers at all dose levels, and at the highest dose tested (2.0μg), the vaccine produced a 100% neutralizing antibody seroconversion rate in fibroblast cells, and a 31% seroconversion rate in epithelial cells after the third immunization. Dr. Gantt will provide an overview of this data, and will also highlight the correlate observed between epithelial cell neutralizing antibody activity and higher gB antibody binding titer levels.
According to IDWeek’s website, IDWeek identifies late breaker abstracts as highly competitive, with less than 10 percent of submissions chosen for presentation, and abstracts must contain new, novel, cutting-edge information in order to be considered.
-- Session: 213. Late Breaker Oral Abstracts: Influenza and Vaccines -- Date: Saturday, October 6, 2018 -- Time: 11:10 AM PDT -- Event Website: https://www.idweek.org
About VBI Vaccines Inc.
VBI Vaccines Inc. (“VBI”) is a commercial-stage biopharmaceutical company developing a next generation of vaccines to address unmet needs in infectious disease and immuno-oncology. VBI’s first marketed product is Sci-B-Vac®, a hepatitis B (HBV) vaccine that mimics all three viral surface antigens of the hepatitis B virus; Sci-B-Vac® is approved for use in Israel and 10 other countries. VBI’s eVLP Platform technology enables the development of enveloped virus-like particle (eVLP) vaccines that closely mimic the target virus to elicit a potent immune response. VBI is advancing a pipeline of eVLP vaccines, with lead programs in cytomegalovirus (CMV) and glioblastoma (GBM). VBI is headquartered in Cambridge, MA with research operations in Ottawa, Canada and research and manufacturing facilities in Rehovot, Israel.
-- Website Home: http://www.vbivaccines.com/ -- News and Insights: http://www.vbivaccines.com/wire/ -- Investors: http://www.vbivaccines.com/investors/
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