LONDON--(BUSINESS WIRE)--May 16, 2018--MiNA Therapeutics, the pioneer in RNA activation therapeutics, today announced that it will present preliminary results from its Phase I study of small activating RNA (saRNA) candidate MTL-CEBPA in liver cancer at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place in Chicago from June 1 – 5. The data will be featured in a Poster Discussion Session in the Developmental Therapeutics – Clinical Pharmacology and Experimental Therapeutics session. MiNA will announce the results through a press release following the presentation.

Poster Discussion Session details:

Title: Preliminary results of a first-in-human, first-in-class phase I study of MTL-CEBPA, a small activating RNA (saRNA) targeting the transcription factor C/EBP-α in patients with advanced liver cancer

Abstract No: 2509

Session: Developmental Therapeutics—Clinical Pharmacology and Experimental Therapeutics

Date / Time: June 4, 2018 at 3:00pm – 4:15pm

Location: S406


MTL-CEBPA consists of a double stranded RNA formulated into a SMARTICLES ® liposomal nanoparticle and is designed to activate the CEBPA gene. By restoring CEBPA expression to normal levels, MTL-CEBPA has been demonstrated to attenuate or reverse liver disease in a range of pre-clinical studies including models of liver cancer, liver cirrhosis, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). MTL-CEBPA is currently under evaluation in OUTREACH, a first-in-human Phase I clinical study in patients with severe liver cancer. The multi-centre Phase I study is assessing the safety and tolerability of MTL-CEBPA in patients with advanced liver cancer who are ineligible or resistant to standard therapies. To learn more about the OUTREACH clinical study, please visit our listing at

About MiNA Therapeutics

Harnessing the innate mechanism of gene activation, MiNA Therapeutics’ platform enables the development of new medicines that restore normal function to patients’ cells. We are applying our technology and clinical know-how to transform the therapy landscape of severe liver and other diseases.

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CONTACT: MiNA Therapeutics

Robert Habib, CEO

Phone: +44 208 811 6700


Media requests:

Gretchen Schweitzer or Joanne Tudorica

Trophic Communications

Phone: +49 89 2388 7735 or +49 172 861 8540



SOURCE: MiNA Therapeutics

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PUB: 05/16/2018 05:00 PM/DISC: 05/16/2018 05:00 PM