SAN SEBASTIAN, Spain (AP) _ Francesco Casagrande of Italy today won his second consecutive San Sebastian Classic, a World Cup cycling event.

A flat tire knocked out Tour de France winner Lance Armstrong.

The American dropped quit about 25 miles from the finish, after getting a puncture as he approached the traditionally decisive Jaizkibel mountain pass among the leading pack of cyclists.

The puncture apparently ended Amstrong's hopes of being among the leaders at the finish line and he decided to abandoned the race rather than change the wheel and carry on.

And, it was on the Jaizkibel pass that Casagrande opened up his lead, crossing the finishing line 43 seconds ahead of the pack of 25 riders. Rik Verbrougghe of Belgium finished second, followed by Italy's Guiliano Figuera.

Casagrande covered the 143 miles in 5 hours, 15 minutes and 29 seconds in the sixth of 10 one-day races making up cycling's World Cup.

Armstrong had said the San Sebastian would be his last race of the European season.

Saturday's race was the first world class event since the Tour de France in July.