BLOOMINGTON, Ind. (AP) _ Now Mike Alstott's college career is complete.

Already Purdue's career rushing and scoring leader, Alstott broke the Boilermakers' single-season rushing record and scored three touchdowns Friday in a 51-14 victory over Indiana.

Purdue took a 24-0 lead in the second quarter and put the Hoosiers away with three touchdowns in the third period. Alstott, who finished with a career-high 264 yards, set up one score with a 59-yard run, then scored on a 62-yard run the next series. He also set up a 3-yard TD run by Edwin Watson with a 35-yard carry early in the fourth quarter.

Alstott, who increased his earlier career records to 3,635 rushing yards, 39 rushing touchdowns and 256 points, raised his season total to 1,436 yards, breaking the former Purdue record of 1,361 set in 1972 by Otis Armstrong.

The 264 yards by Alstott also marked the second-highest rushing performance in the Indiana-Purdue series, trailing only Armstrong's 276 in 1972.

Five of the previous six Old Oaken Bucket games between the two intrastate rivals had been decided by seven points or less, but the Boilermakers took the Hoosiers out of this one early and never let up.

The 51 points by Purdue (4-6-1, 2-5-1 Big Ten) were the most by the Boilermakers since they beat Indiana 51-6 in 1966, and the margin of victory was the most since Indiana won 52-7 in 1988.

The Hoosiers (2-9, 0-8) netted 5 yards offense in the first quarter, got their first first down on a penalty late in the opening period and didn't cross midfield until the closing minutes of the second quarter, when Purdue already was ahead 24-0.

Indiana scored on a 3-yard run by quarterback Adam Greenlee just before halftime, but the Hoosiers' Dorian Wilkerson fumbled the second-half kickoff. Purdue scored again three plays later on a 2-yard run by Corey Rogers.

Purdue repeatedly burned the Hoosiers on big plays, including a 47-yard run by Watson on the opening series to set up the first touchdown run by Alstott, a 1-yarder. Midway through the quarter, a roughing-the-passer penalty on Indiana kept alive another Purdue drive that ended with a 26-yard field goal by Brad Bobich.

Early in the second quarter, a 69-yard pass from Rick Trefzger to Craig Allen set up a 7-yard touchdown pass to Brian Alford. On the next Purdue possession, a 31-yard pass to Alford and 24-yard run by Alstott helped the Boilermakers to the Indiana 7. After a holding penalty, Rogers ran 6 yards and Trefzger passed 10 yards to Alford for another touchdown.

Indiana finally moved into Purdue territory with a 29-yard pass from Greenlee to Sean Glover late in the second quarter. Five more passes took the Hoosiers to the 6, and a pair of 3-yard runs by Greenlee gave Indiana a touchdown 59 seconds before halftime. Alex Smith, who set a Big Ten freshman rushing record with 245 yards against Purdue last year, had only 64 yards and scored Indiana's second touchdown on a 6-yard run midway through the third quarter.

Chris Dittoe replaced Greenlee in the fourth quarter and took the Hoosiers to the Purdue 8 before losing the ball on downs.